Understanding lactic acidosis in paracetamol (acetaminophen) poisoning
نویسندگان
چکیده
منابع مشابه
Lactic Acidosis
Lactic acidosis is a form of metabolic acidosis due to the inadequate clearance of lactic acid from the blood. Lactate is a byproduct of anaerobic respiration and is normally cleared from the blood by the liver, kidney and skeletal muscle. Lactic acidosis occurs when the body's buffering systems are overloaded and tends to cause a pH of ≤7.25 with plasma lactate ≥5 mmol/L. It is usually caused ...
متن کاملLactic acidosis.
A 33-year-old male was admitted to Michael Reese Hospital and Medical Center for evaluation of weight loss, dyspnea, and fever. He had factor Vill-deficient hemophilia and had been chronically ill over several months with a cough productive of scanty sputum, weight loss of 15 Ibs, low-grade fever, and progressive dyspnea on exertion. The medical history was notable for right total hip replaceme...
متن کاملLactic Acidosis
by exchanige transfusioin. Muscle activity is associate(l with a higher blood lactate concenltrationi thani is observed in iron-replete aniimals. The accumulation of lactate is a result of excessive productioni as lactate clearancie fromn the 1)loo0( was shown to be unaffecte(l. By acljusting the work loa(l to a lower level, it was possible to (livide iron-deficient animilals into two groups, o...
متن کاملAcetaminophen Poisoning
Acetaminophen is one of the most popular nonnarcotic analgesic–antipyretic agents available. Inappropriate use of this agent can lead to significant morbidity and mortality secondary to hepatic necrosis. Several patient-specific factors impact its metabolism and the subsequent production of its toxic metabolite when consumed in excess. Rapid diagnosis and treatment with N-acetylcysteine in the ...
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Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. Debate exists about its primary site of action, which may be inhibition of prostaglandin (PG) synthesis or through an active metabolite influencing cannabinoid receptors. Prostaglandin H(2) synthetase (PGHS) is the enzyme responsible for metabolism of arachidonic acid to the unsta...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2010
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.2010.03765.x